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عمومی::
پروتئین tau فسفریل دار
The present inventors also administered the monoclonal mouse antibodies to model mice of cognitive disorders which showed abnormal expression of phosphorylated tau proteins, and confirmed that improvement in cognitive functions was observed (WO2013/180238A).
[0013] In further aspects, the humanized antibody or fragment or derivative thereof has an improved selective affinity with the phosphorylated tau protein (or tau peptide, e.g.
[0049] FIG. 10A - FIG. 10E show comparable binding characteristics of the parent mouse antibody (FIG. 10A), the chimeric antibody (FIG. 10B), and selected humanized antibody variants (FIG. 10C-10E) to the S413-phosphorylated Tau protein in brain homogenates from Alzheimer's disease patients.
In certain embodiments, the KD value is measured with a phosphorylated Tau protein.
, the phosphorylated Tau protein or the phosphorylated peptide) immobilized.
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